Table 4. Characteristics of the SNPs near or in CD36 and GNAT3 genes and their association with MS (NCEP/ATPIII).
Gene | SNP | Major/minor alleles* | Physical distance (bp)* | Location* | Minor allele frequency (MAF) | P-value |
---|---|---|---|---|---|---|
GNAT3 | SNP1 (rs799975) | G/C | 79920950 | downstream of 3′-UTR | 0.228 | 0.0414 |
SNP2 (rs2944398)a | C/T | 79924797 | near 3′-UTR | 0.425 | 0.0326 | |
SNP3 (rs6942728) | T/C | 79932864 | intron | 0.048 | 0.0437 | |
SNP4 (rs1473122)a | A/T | 79933295 | intron | 0.380 | 0.0271 | |
SNP5 (rs799929)a | A/G | 79935512 | intron | 0.403 | 0.0737 | |
SNP6 (rs6961082) | C/A | 79938905 | intron | 0.012 | 0.4313 | |
SNP7 (rs11760281) | G/A | 79942485 | intron | 0.442 | 0.0003 | |
SNP8 (rs10280807) | T/C | 79946464 | intron | 0.093 | 0.5679 | |
SNP9 (rs6467212)b | A/G | 79955940 | intron | 0.060 | 0.4319 | |
SNP10 (rs10234980) | C/T | 79958990 | intron | 0.035 | 0.8846 | |
SNP11 (rs1524600)b | C/T | 79976239 | intron | 0.067 | 0.5536 | |
CD36 | SNP1 (rs1194197) | T/C | 80013542 | upstream of 5′-UTR1 | 0.476 | 0.0044 |
SNP2 (rs1194182)c | G/C | 80069440 | 5′-UTR1 | 0.375 | 0.0164 | |
SNP3 (rs1984112) | A/G | 80080856 | Intron1 | 0.266 | 0.2819 | |
SNP4 (rs1761667)c | A/G | 80082875 | intron1 | 0.378 | 0.0431 | |
SNP5 (rs57312550)d | C/A | 80090631 | intron1 | 0.070 | 0.4929 | |
SNP6 (rs59637606)d | A/G | 80090743 | intron1 | 0.070 | 0.5638 | |
SNP7 (rs62461694) | T/C | 80090989 | intron1 | 0.043 | 0.6636 | |
SNP8 (rs2151916)e | T/C | 80091319 | intron1 | 0.272 | 0.4414 | |
SNP9 (rs2366855)f | A/T | 80091391 | intron1 | 0.445 | 0.0898 | |
SNP10 (new) | G/T | 80105623 | near 5′-UTR2 | 0.022 | 0.5163 | |
SNP11 (rs1049654)f | C/A | 80113391 | 5′-UTR2 | 0.413 | 0.2377 | |
SNP12 (rs3211805)g | G/T | 80113512 | intron1 & 2 | 0.004 | 0.4243 | |
SNP13 (rs997906)e | A/T | 80117771 | intron1 & 2 | 0.244 | 0.8259 | |
SNP14 (rs3173798) | T/C | 80123786 | intron1 & 2 | 0.145 | 0.0481 | |
SNP15 (rs3211891)g | T/C | 80128284 | intron1 & 2 | 0.004 | 0.4248 | |
SNP16 (rs3211956) | T/G | 80141698 | near 3′-UTR1; intron2 | 0.056 | 0.2740 | |
SNP17 (rs7755)h | G/A | 80144207 | 3′-UTR2 | 0.324 | 0.5031 | |
SNP18 (rs1049673)h | C/G | 80144286 | 3′-UTR2 | 0.318 | 0.3493 |
(NCBI build36; dbSNP BUILD127);
Transscript NM_001001547.1,
Transscript NM_001001548.2;
Three markers are in strong LD with each other (r2 ≥ 0.84);
Two markers are in strong LD with each other (r2 = 0.90);
Two markers are in strong LD with each other (r2 = 0.97);
Two markers are in strong LD with each other (r2 = 1.00);
Two markers are in strong LD with each other (r2 = 0.86);
Two markers are in strong LD with each other (r2 = 0.88);
Two markers are in strong LD with each other (r2 = 1.00);
Two markers are in strong LD with each other (r2 = 0.99)