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Minimal Inhibitory Concentrations of β-lactones for Mycobacteria
| Compound | MIC (μg/mL) | |
|---|---|---|
| M. smegmatis MC2115 | M. tuberculosis H37Rv | |
| 2 | 250 | Not tested |
| 3 | 150 | Not tested |
| 4 | 45 | 47 |
| 7 | 10 | 28 |
β-lactone minimal inhibitory concentrations (MICs) for M. smegmatis and M. tuberculosis. MICs of representative antibacterial drugs against M. tuberculosis H37Rv are as follows: moxifloxacin - 8 μg/mL, isoniazid - 2 μg/mL, kanamycin - 1.2 μg/mL, streptomycin - 16 μg/mL, ethambutol - 4 μg/mL (49).
