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. Author manuscript; available in PMC: 2015 Jan 8.
Published in final edited form as: ACS Chem Biol. 2013 Oct 4;8(12):2669–2677. doi: 10.1021/cb400577b

Table 3.

Minimal Inhibitory Concentrations of β-lactones for Streptomyces bacteria

Compound Strain MIC (μg/mL)
graphic file with name nihms-529804-t0001.jpg WT >800
Δ clpP 1/2::apr >800
Δ clpP 3/4::apr 600
S. griseus 650
graphic file with name nihms-529804-t0002.jpg WT >800
Δ clpP 1/2::apr >800
Δ clpP 3/4:: apr 550
S. griseus 580
graphic file with name nihms-529804-t0003.jpg WT >800
Δ clpP 1/2::apr 300
Δ clpP 3/4::apr 250
S. griseus 250

β-lactone minimal inhibitory concentrations (MICs) for wild-type S. coelicolor, S. coelicolor clpP1clpP2 and clpP3clpP4 null strains, and S.griseus. The β-lactones are partially insoluble at concentrations above 800 μg/mL.