Table 3.
Compound | Strain | MIC (μg/mL) |
---|---|---|
WT | >800 | |
Δ clpP 1/2::apr | >800 | |
Δ clpP 3/4::apr | 600 | |
S. griseus | 650 | |
WT | >800 | |
Δ clpP 1/2::apr | >800 | |
Δ clpP 3/4:: apr | 550 | |
S. griseus | 580 | |
WT | >800 | |
Δ clpP 1/2::apr | 300 | |
Δ clpP 3/4::apr | 250 | |
S. griseus | 250 |
β-lactone minimal inhibitory concentrations (MICs) for wild-type S. coelicolor, S. coelicolor clpP1clpP2 and clpP3clpP4 null strains, and S.griseus. The β-lactones are partially insoluble at concentrations above 800 μg/mL.