Table 1.

Gene Expression of Apoptosis-related Genes After Knockdown C-MYC, PVT1 and miR-1204 in MSTO-211H Cell Lines

	Fold Change
Gene Name	siC-MYC	siPVT1	Anti-miR-1204	Gene Description	Function
Genes upregulated
LTB	17.56	7.31	5.25	Lymphotoxin beta	Pro-apoptotic
BIRC7	9.96	−1.61	8.83	Baculoviral IAP repeat-containing protein 7	Anti-apoptotic
BCL2L14	9.43	4.35	6.57	BCL2 like protein 14	Pro-apoptotic
PYCARD	9.59	−4.06	9.92	PYD and card domain-containing protein	Pro-apoptotic
BCL2A1	3.79	−1.23	1.41	BCL2 -related protein A1	Anti-apoptotic
FASLG	3.29	3.03	1.27	FAS ligand	Pro-apoptotic
BIRC2	2.93	1.66	2.22	Baculoviral IAP repeat-containing protein 2	Anti-apoptotic
TNFRSF1B	0.89	2.12	1.50	Tumor necrosis factor receptor superfamily member 1B	Pro-apoptotic
Genes downregulated
NFKB1	−2.15	1.49	1.01	Nuclear factor NF-kappa-B p105 subunit	Anti-apoptotic
BBC3	−2.20	−1.17	1.01	BCL2 binding component 3	Pro-apoptotic
TNFRSF21	−2.50	1.21	−1.75	Tumor necrosis factor receptor superfamily member 21	Pro-apoptotic
BCL2L1	1.11	−2.02	−1.35	BCL2 like 1	Anti-apoptotic
BCL2	−1.47	−2.13	−1.05	B-cell lymphoma 2	Anti-apoptotic
ICEBERG	1.26	−6.95	−5.31	Caspase 1 inhibitor	Anti-apoptotic
CASP5	−1.08	−9.52	−2.47	Caspase 5, apoptosis related cysteine protease	Pro-apoptotic
TNF	−1.43	−11.48	−1.62	Tumor necrosis factor	Pro-apoptotic
BIRC8	1.10	−42.69	−2.47	Baculoviral IAP repeat-containing protein 8	Anti-apoptotic

Bold, ≥2.0-fold change of expression, p < 0.05