Table 3.
Scenarios to examine the effect of uncertainty in the model parameters
| Variation in | Scenario | Reference |
|---|---|---|
| 1. Accuracy of screening tests (symptom, CXR) | a. High sensitivity, low specificity* | [5] |
| b. Low sensitivity, high specificity* | [5] | |
| 2. Accuracy of confirmatory tests (SSM, XP) | a. High sensitivity, low specificity* | [14, 15, 19, 20] |
| b. Low sensitivity, high specificity* | [14, 15, 19, 20] | |
| 3. Specificity of SSM, XP | Assume 98% specificity for SSM and XP | [22] |
| 4. Proportion of persons with negative SSM or XP receiving clinical diagnosis | a. 0% | |
| b. 100% | ||
| 5. Accuracy of clinical diagnosis | Entirely based on CXR diagnosis | [18] |
| 6. Accuracy of screening tests in different settings | a. Sub Saharan Africa/high HIV-population | [5] |
| b. Asia/low HIV population | [5] |
*set to the extremes of the ranges shown in Table 1.