Table 3.
Ten co-regulation motifs and their occurrence frequencies in the background network and the activated network
| Motif ID | Network | Occurrence | Z-Score |
|---|---|---|---|
| M1 | Background | 1541 | 24.114 |
| Active | 16 | 153.470 | |
| M2 | Background | 21317 | 8.412 |
| Active | 209 | 2.356 | |
| M3 | Background | 45171 | -3.933 |
| Active | 109 | -54.482 | |
| M4 | Background | 27987 | 3.685 |
| Active | 153 | 1.053 | |
| M5 | Background | 187341 | -1.152 |
| Active | 1647 | -20.769 | |
| M6 | Background | 2931 | -1.091 |
| Active | - | - | |
| M7 | Background | 20060 | 1.017 |
| Active | 59 | 0.914 | |
| M8 | Background | 3226 | -0.624 |
| Active | 13 | 25.591 | |
| M9 | Background | 481293 | -0.478 |
| Active | 38 | 0.626 | |
| M10 | Background | 88102 | -0.230 |
| Active | 273 | -24.802 |
Motifs are ordered according to their absolute Z-scores in the background regulatory network, which are calculated using FANMOD [50]. Motifs 'M1’, 'M2’, and 'M3’ are statistically significant in both the background and the activated regulatory networks (threshold of 2). 'M5’, 'M8’ and 'M10’ are not statistically significant in the background regulatory network, while they become significant in the activated regulatory network.