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. 2015 Jan 8;11(1):e1004916. doi: 10.1371/journal.pgen.1004916

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© 2015 Baker et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Predicted timeline for the origin of Prdm9 alleles based on SNP frequency found at hotspots comparing B6 and CAST to SPRET. PRDM9^Cst hotspots show an increase in SNPs in the B6 background, suggesting this allele was active in a shared lineage between M.m. castaneus and M.m. domesticus. PRDM9^Dom2 hotspots do not have increased SNPs in the CAST background suggesting this allele was never active in M.m. castaneus. (B) The PRDM9/hotspot lifecycle. Evolutionary erosion driven by biased PRDM9 initiation of recombination decreases hotspot activity over time at many hotspots in parallel. Mutation of Prdm9 creates a new binding domain subsequently shifting the genome-wide position of hotspots.