Table 1.
Comparison of Alzheimer’s disease groups with cerebrovascular changes (AD+CVC) and without cerebrovascular changes (AD−CVC) on demographic and clinical characteristics
| AD+CVC, n = 50 mean (sd) |
AD−CVC, n = 34 mean (sd) |
t or χ2 value |
p- value |
|||
|---|---|---|---|---|---|---|
| Demographics | ||||||
| Age at Vascular Risk Assessment, yrs | 73.18 | (7.97) | 70.38 | (6.33) | 1.71 | .09 |
| Education, yrs | 13.00 | (3.21) | 13.53 | (2.67) | .79 | .43 |
| Women/men | 26/24 | 16/18 | .20 | .66 | ||
| APOE Genotype (ε4+/ε4−) | 34/16 | 22/9 | .08 | .78 | ||
| Diagnosis at Vascular Risk Assessment | 40/10 | 28/6 | .07 | .79 | ||
| (Probable AD/Possible AD) | ||||||
| Age at Dementia Onset | 69.24 | (8.28) | 64.85 | (6.35) | 2.59 | .01 |
| Age at Death | 79.10 | (8.07) | 75.41 | (6.01) | 2.27 | .03 |
| Duration of Dementia | 9.86 | (4.14) | 10.36 | (2.98) | .60 | .55 |
| Time Between Vascular Risk Assessment and Death, yrs | 6.11 | (3.35) | 5.21 | (2.48) | 1.50 | .14 |
| Cognitive Functioning (raw scores) | ||||||
| DRS Total Score | 104.42 | (25.24) | 98.56 | (25.59) | 1.04 | .30 |
| DRS Attention | 32.47 | (5.51) | 30.91 | (7.72) | 1.07 | .29 |
| DRS Initiation/Perseveration | 24.98 | (9.10) | 21.65 | (9.22) | 1.63 | .11 |
| DRS Construction | 4.45 | (1.67) | 4.15 | (1.69) | .81 | .42 |
| DRS Conceptualization | 31.00 | (6.64) | 28.74 | (8.11) | 1.39 | .17 |
| DRS Memory | 12.76 | (5.20) | 11.50 | (5.55) | 1.05 | .30 |
Abbreviations: APOE = apolipoprotein E; DRS = Dementia Rating Scale