Table 1. Cre/loxP-mediated chromosome 15 rearrangements.
Chromosome 15 deletions | Deletion Size (base pairs) | DRT/DMC# | Instabilityq | ||
Clone Name | Integration Site | Proximal | Distal | Clones + | Clones + |
Δ268F-6a | cen-58,733,512 | >18,125,231 | 0(1) | 0(1) | |
Δ268F-5a,d,m | 76,732,559–76,791,779 | 66,964–126,184 | 0(3) | 0(3) | |
Δ268F-6b,c,d | 76,732,559–76,791,780 | 66,964–126,184 | 0(3) | 0(3) | |
loxP-RT | 76,858,743–76,858,758 | N/A | N/A | N/A | N/A |
Δ268-15a,c | 76,860,843 | 2,085 | 0(2) | 0(2) | |
Δ268-18a,d,m,n | 76,982,805 | 124,047 | 0(4) | 3(4) | |
Δ268-4c,f,k,q,s,t | 76,994,171 | 135,413 | 3(3) | 3*(6) | |
Δ268-4a,e,g,m,p,s | 77,020,070 | 161,312 | 2(4) | 2*(6) | |
Δ268-18t,x | 77,113,970 | 255,212 | 1(2) | 2(2) | |
Δ268-5c,d | 82,480,936 | 5,622,178 | 2(2) | 2*(2) | |
Δ268-4d | 89,692,218 | 12,833,460 | 1(1) | 0(1) |
The number of clones that showed DRT/DMC (total clones scored).
The number of clones that showed>10% of rearrangements of chromosome 15 (total clones scored).
*At least one clone with>90% of cells containing chromosome 15 rearrangements.