Table 3. Defined T cell targets in individual R463F.
18mer Peptides (s) | Optimal epitope | ||||||
Protein | Amino acid positiona | Designation | Amino acid sequence | Amino acid positiona | Designation | Amino acid sequence | HLAb |
Gag | 132–149 | Gag 132–149 | YPVVQNAQGQWVHQNFSP | 140–147 | Gag 140–147 | GQWVHQNF | B1503** |
140–157 | Gag 140–157 | GQWVHQNFSPRTLNAWVK | 140–147 | Gag 140–147 | GQWVHQNF | ||
292–309 | Gag 292–309 | PFRDYVDRFFKTLRAEQA | |||||
381–398 | Gag 381–398 | GNFKGQRKIKCFNCGKE | |||||
Pol | 409–426 | Pol 409–426 | VNDIQKLVGKLNWASQIY | 417–426 | Pol 417–426 | GKLNWASQIY | A3002* |
417–434 | Pol 417–434 | GKLNWASQIYAGIKVKQL | 417–426 | Pol 417–426 | GKLNWASQIY | ||
897–914 | Pol 897–914 | IHNFKRKGGIGGYSAGER | |||||
929–946 | Pol 929–946 | QKQITKIHKFRVYYRDSR | 933–942 | Pol 933–942 | TKIHKFRVYY | B1503* | |
969–986 | Pol 969–986 | NNDIKVVPRRKAKIIRDY | 977–986 | Pol 977–986 | RKAKIIRDY | B1503* | |
977–994 | Pol 977–994 | RRKAKIIRDYGKQMAGDD | 978–986 | Pol 978–986 | |||
985–1002 | Pol 985–1002 | DYGKQMAGDDCVAGRQDE | |||||
Env | 1–15 | Env 1–15 | MRVMGTQMNYQNLWRWGI | ||||
334–351 | Env 334–351 | SKAEWNETVRRVAEQLEK | |||||
342–360 | Env 342–360 | VRRVAEQLEKYFKNKTIK | |||||
402–420 | Env 402–420 | TVNATRSENDTINLPCRI | |||||
Tat | 33–50 | Tat 33–50 | HCLVCFQHKGLGISYGRK | 38–47 | Tat 38–47 | FQHKGLGISY | B1503* |
Nef | 177–194 | Nef 177–194 | EGETLQWKFDSYLAFKHI | 183–191 | Nef 183–191 | WKFDSYLAF | B1503** |
relative to HXB2.
presenting HLA allele previously described (*) or predicted (**).