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. 2015 Jan 8;9(1):e3445. doi: 10.1371/journal.pntd.0003445

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© 2015 Kam et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Patient serum samples caused by non-CHIKV alphaviruses infections (n = 19) and flaviviruses infections (n = 60) were screened for cross-reactivity against CHIKV E2EP3 by peptide-based ELISA at a dilution of 1∶4000. A, Pie-chart shows the percentage of non-CHIKV alphaviruses-infected patients samples with positive or negative anti-E2EP3 antibody response. B, Pie-chart shows the percentage of flaviviruses-infected patient samples with positive or negative anti-E2EP3 antibody response. C - D, Pie-chart shows the percentage of DENV-infected and non-DENV flaviviruses-infected patient samples with positive or negative anti-E2EP3 IgG antibody response respectively. E, Detection of CHIKV E2EP3 by serum samples of unknown infections. Serum samples (n = 71) of febrile patients from unknown cause of infections were screened by peptide-based ELISA at a dilution of 1∶4000. Pie-chart shows the percentage of patients' samples with positive or negative anti-E2EP3 antibody response. F, Bar-chart shows the number of non-CHIKV alphaviruses-infected, E2EP3 cross-reactive samples with and without CHIKV neutralizing activity against the two CHIKV isolates (CHIKV (A226) and CHIKV (A226V)).