Table 1.
Pearson correlation matrixes showing Pearson correlation coefficients (r) of resistance between pairs of antibiotics for a) E. coli , b) K. pneumonia , c) K. oxytoca , d) E. cloacae , e) P. aeruginosa
| a) Pearson correlation matrix (r) for E. coli | ||||||
|---|---|---|---|---|---|---|
| Cefazolin | Ceftriaxone | Ciprofloxacin | TMP-SMX | Pip-tazo | Tic-clav | |
| Cefazolin (n = 1783) | ||||||
| Ceftriaxone (n = 1783) | 0.808 | |||||
| Ciprofloxacin (n = 1783) | 0.487 | 0.290 | ||||
| TMP-SMX (n = 1783) | 0.770 | 0.503 | 0.871 | |||
| Pip-tazo (n = 846) | 0.702 | 0.623 | 0.973 | 0.865 | ||
| Tic-clav (n = 1063) | 0.885 | 0.299 | 0.733 | 0.839 | nd | |
| b) Pearson correlation matrix (r) for K. pneumoniae | ||||||
| Cefazolin | Ceftriaxone | Ciprofloxacin | TMP-SMX | Pip-tazo | Tic-clav | |
| Cefazolin (n = 480) | ||||||
| Ceftriaxone (n = 480) | 0.935 | |||||
| Ciprofloxacin (n = 480) | 0.630 | 0.566 | ||||
| TMP-SMX (n = 480) | 0.719 | 0.689 | 0.274 | |||
| Pip-tazo (n = 163) | 0.917 | 0.982 | 0.886 | 0.778 | ||
| Tic-clav (n = 295) | 0.893 | 0.677 | 0.648 | 0.635 | nd | |
| c) Pearson correlation matrix (r) for K. oxytoca | ||||||
| Cefazolin | Ceftriaxone | Ciprofloxacin | TMP-SMX | Pip-tazo | Tic-clav | |
| Cefazolin (n = 127) | ||||||
| Ceftriaxone (n = 127) | 0.576 | |||||
| Ciprofloxacin (n = 127) | 0.619 | 0.952 | ||||
| TMP-SMX (n = 127) | − 0.598 | −0.005 | −0.184 | |||
| Pip-tazo (n = 71) | 0.011 | −0.222 | −0.349 | −0.174 | ||
| Tic-clav (n = 65) | 0.649 | 0.773 | 0.773 | 0.013 | nd | |
| d) Pearson correlation matrix (r) for E. cloacae | ||||||
| Ceftriaxone | Ciprofloxacin | TMP-SMX | Pip-tazo | Tic-clav | ||
| Ceftriaxone (n = 170) | ||||||
| Ciprofloxacin (n = 170) | 0.688 | |||||
| TMP-SMX (n = 170) | 0.611 | 0.172 | ||||
| Pip-tazo (n = 83) | 0.927 | 0.542 | 0.781 | |||
| Tic-clav (n = 96) | 0.944 | 0.613 | 0.781 | nd | ||
| e) Pearson correlation matrix (r) for P. aeruginosa | ||||||
| Ceftazidime | Ciprofloxacin | Pip-tazo | Tic-clav | |||
| Ceftazidime (n = 115) | ||||||
| Ciprofloxacin (n = 115) | −0.457 | |||||
| Pip-tazo (n = 60) | 0.177 | 0.225 | ||||
| Tic-clav (n = 65) | 0.888 | −0.100 | nd | |||
Number of isolates (n) included in each matrix is listed for each row. Pearson coefficients (r) which are bolded represent pairs with p values ≤ 0.05, while those that are bolded and italicized trended towards significance with p values > 0.05 ≤ 0.07. Note: TMP-SMX is trimethoprim-sulfamethoxazole, Pip-tazo is piperacillin-tazobactam, Tic-clav is ticarcillin-clavulanate; nd is not determined as isolates did not consistently have both Pip-tazo and Tic-clav susceptibilities reported.