Skip to main content
. 2015 Jan 8;10(1):e0116566. doi: 10.1371/journal.pone.0116566

Figure 10. Oral administration of ground cinnamon switches Th1 to Th2 in vivo in EAE in PLP-TCR Tg mice.

Figure 10

Spleens of control, EAE (14 dpi) and either cinnamon- or vehicle-treated EAE mice (14 dpi receiving cinnamon/vehicle from 8 dpi) were analyzed for the mRNA expression of Th1-specific factors (Tbet and IFN-γ) (A) and Th2-specific factors (GATA3 and IL-10) (B) by semi-quantitative RT-PCR. LNC isolated from different groups of mice were analyzed by FACS for IFN-γ & CD4 (C) and IL-4 & CD4 (D). The MFI of IFN-γ (E) and IL-4 (F) in CD4+ population were calculated by using the CellQuest software. Data are mean ± SEM of 3 mice per group. a p< 0.001 vs normal; bp<0.001 vs EAE.