Table 2.
Mec-1 | OSU-CLL | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
C | 1 μM | 2 μM | 3 μM | 4 μM | C | 1 μM | 2 μM | 3 μM | 4 μM | |
P-FAKTyr397 | 6.5 | 8.2 | 6.2 | 5.1 | 5.0 | 2.2 | 1.9 | 2.4 | 2.6 | 2.4 |
P-FAKTyr925 | 4.2 | 3.6 | 4.7 | 4.0 | 3.5 | 2.8 | 3.5 | 4.3 | 3.7 | 3.2 |
P-BTK | 5.0 | 6.2 | 6.2 | 5.8 | 5.7 | 7.5 | 7.7 | 9.1 | 9.1 | 8.5 |
P-AKTSer473 | 11.1 | 6.5 | 3.2 | 1.9 | 1.8 | 15.1 | 10.0 | 6.6 | 3.1 | 2.3 |
P-FAKThr308 | 13.6 | 6.9 | 7.1 | 3.7 | 2.8 | 14.3 | 6.5 | 3.6 | 3.3 | 2.4 |
P-Craf | 17.6 | 16.7 | 11.7 | 8.1 | 6.4 | 14.0 | 9.6 | 8.4 | 6.4 | 6.2 |
P-ERK | 15.9 | 7.5 | 2.9 | 2.6 | 2.6 | 12.6 | 6.5 | 7.7 | 7.4 | 7.5 |
P-P38 | 8.4 | 8.1 | 7.1 | 5.7 | 4.5 | 5.6 | 6.4 | 7.0 | 5.8 | 4.1 |
P-GSK3β | 6.3 | 5.2 | 4.8 | 4.1 | 3.0 | 6.9 | 4.9 | 3.9 | 3.3 | 3.6 |
P-PDK1 | 4.3 | 5.0 | 5.4 | 5.0 | 4.3 | 4.3 | 5.0 | 6.6 | 5.8 | 5.2 |