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. 2014 May 26;33(43):5109–5120. doi: 10.1038/onc.2014.125

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Copyright © 2014 Macmillan Publishers Limited

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Knockdown of MCT-1 inhibits tumorigenicity. (a) MDA-MB-468 cells were subcutaneously (s.c.) injected into the nude mice. Tumor volumes were measured weekly. (b) Mice were killed at the end point of 13 weeks. Tumor burdens were reduced markedly upon MCT-1 knockdown (shMCT-1 no. 1) compared with the non-silence control cells (MOCK). (c) Tumor incidences and burdens were analyzed. MCT-1 depletion (shMCT-1 nos. 1, 2 and 3) significantly inhibited tumor growth. (d) Immunohistochemical study detected low levels of p190B and active Src (tyr416) in the tumors emerged from the MCT-1 knockdown cells.