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A genetically-engineered biosensor with selectivity for organoarsenicals. The E. coli cell-based biosensor was genetically modified to eliminate the As(III) binding site. The As(III) binding site in AfArsR is composed of three cysteine residues, Cys95, Cys96 and Cys102 (A). A C102S mutant loses the high-affinity binding of three-coordinate As(III), (B) but retains its affinity for two-coordinate organoarsenicals, such as MAs(III), PhAs(III) and Rox(III) (C).
