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. 2015 Jan 9;5:7697. doi: 10.1038/srep07697

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(A) Structure of iso-GNA. (B) A549, H460, HepG2, Hela and HCT-116 cell were incubated with 0, 2.5, 5, 10 μM of iso-GNA for 24 h. MTT assay was employed to detect cell viability. (C) and (D) Human NSCLC A549 (C) or H460 (D) cells were incubated with 0, 2.5, 5, 10 μM of iso-GNA for various times. MTT assay was employed to detect cell viability. (E) and (F) Mice were injected with or without iso-GNA (20 mg/kg/2 days) after solid tumours grew to 70 mm³, the positive control group was treated with cisplatin (4 mg/kg/two times per week). The solid tumor growth was inhibited by iso-GNA as measured by relative tumour volume(E) and weight (F). **p < 0.01, in comparison with the untreated group.