Table 1.

Summary of the voltage dependence of activation and inactivation for hERG1 concatenated tetramers

			Extracellular solution
Channel type	V0.5 (mV)	z (e0)	98Na2K	96K4Na	n
WT4	−52.9 ± 3.6	1.11 ± 0.02	•		5
ST1/WT3	+29.8 ± 2.7	1.64 ± 0.07	•		12
WT3/ST1	+39.9 ± 2.8	1.43 ± 0.04	•		6
ST2/WT2	+41.8 ± 3.3	1.41 ± 0.10	•		12
ST1/WT1/ST1/WT1	+36.1 ± 1.7	1.73 ± 0.09	•		11
ST1/WT1/ST2	+37.5 ± 2.2	1.60 ± 0.10	•		9
ST4	+39.7 ± 3.8	1.52 ± 0.15	•		7
SA1/WT3	−0.1 ± 4.2	0.95 ± 0.04	•		7
SA2/WT2	+3.7 ± 4.1	1.18 ± 0.02	•		5
SA1/WT1/SA1/WT1	+2.9 ± 2.5	1.21 ± 0.06	•		7
SA1/WT1/SA2	+15.2 ± 3.2	1.37 ± 0.08	•		7
SA4	+24.3 ± 5.3	1.29 ± 0.04	•		9
WT4	−50.5 ± 1.9	0.71 ± 0.03		•	5
TA1/WT3	−96.7 ± 4.4	0.66 ± 0.01		•	4
TA2/WT2	−109.2 ± 3.2	0.65 ± 0.01		•	5
TA1/WT1/TA1/WT1	−112.2 ± 5.4	0.66 ± 0.03		•	5
TA1/WT1/TA2	−124.8 ± 3.5	0.77 ± 0.02		•	5
TA4	−134.1 ± 1.6	0.79 ± 0.02		•	5
MC1/WT3	−101.4 ± 3.0	0.59 ± 0.02		•	5
MC2/WT2	−106.5 ± 2.2	0.59 ± 0.02		•	5
MC1/WT1/MC1/WT1	−104.8 ± 2.9	0.67 ± 0.03		•	4
MC1/WT1/MC2	−122.8 ± 4.5	0.61 ± 0.03		•	6
MC4	−141.4 ± 3.0	0.62 ± 0.03		•	6

Data are expressed as means ± s.e.m. (n = number of oocytes).