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. 2014 Aug 1;592(Pt 20):4507–4521. doi: 10.1113/jphysiol.2014.277616

Figure 9. Inhibition of ADAM17 with TAPI-2 protects mouse lung from LPS/VILI induced injury and decreases p44/42 MAPK activation.

Figure 9

A, decrease in static compliance is prevented by TAPI-2 vs. vehicle. B, bronchoaveolar fluid protein is significantly lower in TAPI 2 vs. vehicle. C, BAL TNFα levels are suppressed by TAPI-2. D, Western blot demonstrating phosphorylation of p44/42 MAPK is significantly lower in TAPI 2 vs. vehicle. *P < 0.05, two-tailed t test, †P = 0.045 one-tailed t test; n = 5 or 6 per group. BAL, bronchoalveolar lavage; MAPK, mitogen-activated protein kinase; TNF, tumour necrosis factor.