Table 2.
The response of the gastric corpus to microinjection of oxytocin engages different pathways in naive and CRF-exposed rats
Naive rats | Rats exposed to CRF | ||
---|---|---|---|
Oxytocin (mg) | Repeat oxytocin (mg) | Oxytocin (mg) | Repeat oxytocin after CRF (mg) |
−173 ± 52.5 | l-NAME (N = 4) −8 ± 7.7* | −103 ± 8.9 | l-NAME (N = 5) −178 ± 31.6 |
−131 ± 21.3 | Bethanechol (N = 4) −375 ± 88.4 | −108 ± 6.5 | Bethanechol (N = 4) −311 ± 129.6 |
−138 ± 20.5 | VIP antagonist (N = 7) −64 ± 20.9 | −138 ± 20.5 | VIP antagonist (N = 7) −23 ± 39.6* |
P < 0.05 vs. Oxytocin alone.