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. 2015 Jan 9;5:7691. doi: 10.1038/srep07691

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(a) Relative anti-DNA IgG levels detected by ELISA in serum at 4 months of age. Anti-DNA IgG production was decreased in MRL/lpr-p21tg compared to MRL/lpr mice. Values show mean ± SD (n = 9 mice; p < 2 × 10⁻⁴). (b) Immunostaining of kidney cryosections, showing reduced immune complex deposition (anti-IgG), CD4⁺ T cell (anti-CD4) and macrophage (anti-F4/80) infiltration in MRL/lpr-p21tg mice at 6 months of age. (c) Evaluation of glomerulonephritis grade (Berdem scale) in representative kidney sections from MRL-Mp, MRL/lpr and MRL/lpr-p21tg mice at 6 months of age showed reduced glomerulonephritis in MRL/lpr-p21tg than in MRL/lpr mice. (d) Kaplan-Meier survival curves indicate the effect of the p21 transgene on MRL/lpr-p21tg mouse lifespan.