Table 4.
Pooled measures for the associations of the UCP2 Ala55Val, 45-bp insertion/deletion, and -866G/A polymorphisms with overweight and obesity.
| Population | Inherited model | Before sensitive analysis |
After sensitive analysis |
Excluded studies in sensitive analysis | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Numbers of cases/controls | Pooled OR (95% CI) |
I2 (%) |
Numbers of cases/controls | Pooled OR (95% CI) |
I2 (%) |
|||||
| FEM | REM | FEM | REM | |||||||
| Ala55Val | ||||||||||
| Overall | Dominant | 2011/2752 | 1.19 (1.04–1.36)⁎ | 1.27 (0.99–1.62) | 65.4 | 1799/2531 | 1.08 (0.94–1.25) | 1.11 (0.91–1.36) | 42.6 | Li (2007), Wang et al. (2009) |
| Recessive | 1687/2638 | 1.24 (1.06–1.45)⁎ | 1.29 (1.06–1.56)⁎ | 24.7 | – | – | – | – | – | |
| Co-dominant 1 | 2011/2752 | 1.12 (0.97–1.29) | 1.17 (0.91–1.50) | 62.0 | 1799/2531 | 1.01 (0.87–1.18) | 1.02 (0.84–1.25) | 35.1 | Li (2007), Wang et al. (2009) | |
| Co-dominant 2 | 1687/2638 | 1.26 (1.05–1.52)⁎ | 1.38 (1.03–1.84)⁎ | 51.3 | 1568/2461 | 1.18 (0.97–1.42) | 1.22 (0.96–1.54) | 25.4 | Sui et al. (2004) | |
| Additive | 2011/2752 | 1.24 (1.09–1.41)⁎ | 1.34 (1.04–1.72)⁎ | 69.5 | 1475/2417 | 1.07 (0.92–1.23) | 1.09 (0.90–1.31) | 33.9 | Li (2007), Wang et al., 2007, Wang et al., 2009 | |
| Over-dominant | 2011/2752 | 1.00 (0.89–1.13) | 1.04 (0.85–1.27) | 54.6 | 1968/2704 | 0.98 (0.86–1.11) | 0.99 (0.83–1.19) | 43.5 | Wang et al. (2009) | |
| Allelic | 2011/2752 | 1.17 (1.07–1.27)⁎ | 1.25 (1.07–1.48)⁎ | 64.6 | 1723/2402 | 1.08 (0.98–1.19) | 1.14 (0.98–1.32) | 46.2 | Li (2007), Sui et al. (2004) | |
| Asian | Dominant | 1586/2126 | 1.24 (1.06–1.44)⁎ | 1.34 (0.99–1.81) | 70.7 | 1050/1791 | 1.02 (0.85–1.21) | 1.03 (0.82–1.31) | 35.0 | Li (2007), Wang et al., 2007, Wang et al., 2009 |
| Recessive | 1262/2012 | 1.28 (1.06–1.55)⁎ | 1.39 (1.06–1.82)⁎ | 37.8 | – | – | – | – | – | |
| Co-dominant 1 | 1586/2126 | 1.15 (0.98–1.36) | 1.22 (0.90–1.67) | 68.0 | 1192/1536 | 1.12 (0.92–1.36) | 1.13 (0.88–1.45) | 29.9 | Kosuge et al. (2008), Li (2007), Wang et al. (2009) | |
| Co-dominant 2 | 1262/2012 | 1.31 (1.06–1.63)⁎ | 1.50 (1.01–2.20)⁎ | 59.9 | 1143/1835 | 1.19 (0.95–1.50) | 1.28 (0.92–1.80) | 41.2 | Sui et al. (2004) | |
| Additive | 1586/2126 | 1.29 (1.11–1.50)⁎ | 1.41 (1.04–1.93)⁎ | 74.0 | 1050/1791 | 1.07 (0.90–1.26) | 1.10 (0.85–1.43) | 49.9 | Li (2007), Wang et al., 2007, Wang et al., 2009 | |
| Over-dominant | 1586/2126 | 1.03 (0.89–1.19) | 1.09 (0.84–1.40) | 61.8 | 1361/1709 | 1.08 (0.92–1.27) | 1.10 (0.88–1.37) | 39.2 | Kosuge et al. (2008), Wang et al. (2009) | |
| Allelic | 1586/2126 | 1.20 (1.08–1.33)⁎ | 1.32 (1.07–1.63)⁎ | 64.6 | 974/1662 | 1.04 (0.93–1.18) | 1.09 (0.91–1.30) | 39.7 | Li (2007), Sui et al. (2004), Wang et al. (2007) | |
| European | Dominant | 425/626 | 1.04 (0.78–1.40) | 1.04 (0.78–1.40) | 0.0 | – | – | – | – | – |
| Recessive | 425/626 | 1.15 (0.87–1.52) | 1.15 (0.87–1.52) | 0.0 | – | – | – | – | – | |
| Co-dominant 1 | 425/626 | 0.99 (0.72–1.35) | 0.99 (0.72–1.35) | 0.0 | – | – | – | – | – | |
| Co-dominant 2 | 425/626 | 1.14 (0.80–1.61) | 1.14 (0.80–1.61) | 0.0 | – | – | – | – | – | |
| Additive | 425/626 | 1.07 (0.80–1.42) | 1.07 (0.80–1.42) | 0.0 | – | – | – | – | – | |
| Over-dominant | 425/626 | 0.92 (0.72–1.18) | 0.92 (0.72–1.18) | 0.0 | – | – | – | – | – | |
| Allelic | 425/626 | 1.07 (0.90–1.28) | 1.07 (0.90–1.28) | 0.0 | – | – | – | – | – | |
| 45-bp insertion/deletion | ||||||||||
| Overall | Dominant | 3416/3260 | 1.02 (0.92–1.13) | 1.01 (0.86–1.17) | 45.7 | – | – | – | – | – |
| Recessive | 3416/3260 | 1.19 (0.95–1.49) | 1.13 (0.85–1.51) | 28.6 | – | – | – | – | – | |
| Co-dominant 1 | 3416/3260 | 1.00 (0.89–1.12) | 0.99 (0.86–1.15) | 33.4 | – | – | – | – | – | |
| Co-dominant 2 | 3416/3260 | 1.16 (0.92–1.46) | 1.08 (0.78–1.51) | 41.4 | – | – | – | – | – | |
| Additive | 3416/3260 | 1.04 (0.93–1.15) | 1.01 (0.86–1.19) | 56.2 | 3111/2752 | 0.97 (0.87–1.09) | 0.96 (0.83–1.12) | 38.7 | Evans et al. (2000) | |
| Over-dominant | 3416/3260 | 0.98 (0.88–1.09) | 0.98 (0.86–1.11) | 20.4 | – | |||||
| Allelic | 3416/3260 | 1.04 (0.95–1.13) | 1.02 (0.89–1.17) | 53.0 | 3111/2752 | 0.98 (0.90–1.08) | 0.98 (0.87–1.10) | 32.2 | Evans et al. (2000) | |
| Asian | Dominant | 1006/1481 | 1.07 (0.88–1.30) | 1.07 (0.86–1.34) | 11.8 | – | – | – | – | – |
| Recessive | 1006/1481 | 0.96 (0.50–1.87) | 0.96 (0.50–1.87) | 0.0 | – | – | – | – | – | |
| Co-dominant 1 | 1006/1481 | 1.08 (0.89–1.32) | 1.09 (0.87–1.36) | 11.8 | – | – | – | – | – | |
| Co-dominant 2 | 1006/1481 | 0.98 (0.50–1.90) | 0.98 (0.50–1.90) | 0.0 | – | – | – | – | – | |
| Additive | 1006/1481 | 1.06 (0.88–1.28) | 1.06 (0.84–1.32) | 15.8 | – | – | – | – | – | |
| Over-dominant | 1006/1481 | 1.08 (0.89–1.32) | 1.09 (0.87–1.36) | 11.4 | – | – | – | – | – | |
| Allelic | 1006/1481 | 1.05 (0.89–1.26) | 1.05 (0.87–1.27) | 5.8 | – | – | – | – | – | |
| European | Dominant | 2410/1779 | 1.00 (0.88–1.13) | 0.98 (0.80–1.20) | 57.5 | 2105/1271 | 0.91 (0.79–1.05) | 0.91 (0.76–1.09) | 33.7 | Evans et al. (2000) |
| Recessive | 2410/1779 | 1.22 (0.96–1.55) | 1.16 (0.82–1.65) | 47.6 | – | – | – | – | – | |
| Co-dominant 1 | 2410/1779 | 0.96 (0.84–1.10) | 0.96 (0.80–1.15) | 42.5 | – | – | – | – | – | |
| Co-dominant 2 | 2410/1779 | 1.18 (0.92–1.51) | 1.12 (0.74–1.68) | 58.5 | 2105/1271 | 1.00 (0.76–1.32) | 0.97 (0.68–1.39) | 34.1 | Evans et al. (2000) | |
| Additive | 2410/1779 | 1.02 (0.91–1.16) | 1.00 (0.80–1.25) | 67.3 | 2105/1271 | 0.93 (0.81–1.06) | 0.92 (0.76–1.12) | 47.4 | Evans et al. (2000) | |
| Over-dominant | 2410/1779 | 0.94 (0.82–1.07) | 0.94 (0.81–1.09) | 22.3 | – | – | – | – | ||
| Allelic | 2410/1779 | 1.03 (0.94–1.14) | 1.01 (0.85–1.21) | 65.3 | 2105/1271 | 0.96 (0.86–1.07) | 0.95 (0.81–1.11) | 44.1 | Evans et al. (2000) | |
| -866G/A | ||||||||||
| Overall | Dominant | 5780/10,196 | 0.93 (0.86–0.99)⁎ | 0.94 (0.83–1.06) | 52.7 | 5440/9940 | 0.95 (0.88–1.02) | 0.97 (0.86–1.02) | 43.9 | Esterbauer et al. (2001) |
| Recessive | 5780/10,196 | 0.96 (0.88–1.05) | 1.02 (0.88–1.18) | 44.9 | – | – | – | – | ||
| Co-dominant 1 | 5780/10,196 | 0.93 (0.86–1.00) | 0.92 (0.82–1.03) | 44.3 | – | – | – | – | ||
| Co-dominant 2 | 5780/10,196 | 0.91 (0.83–1.01) | 0.98 (0.82–1.17) | 52.9 | 5580/9956 | 0.88 (0.80–0.98)⁎ | 0.91 (0.79–1.05) | 28.2 | Srivastava et al. (2010) | |
| Additive | 5780/10,196 | 0.93 (0.86–0.99)⁎ | 0.95 (0.84–1.08) | 60.7 | 5240/9700 | 0.93 (0.86–1.00) | 0.95 (0.85–1.06) | 44.7 | Esterbauer et al. (2001), Srivastava et al. (2010) | |
| Over-dominant | 5780/10,196 | 0.95 (0.89–1.02) | 0.93 (0.85–1.03) | 32.6 | – | – | – | – | – | |
| Allelic | 5780/10,196 | 0.95 (0.91–1.00) | 0.98 (0.90–1.07) | 57.6 | 5580/9956 | 0.94 (0.89–0.99)⁎ | 0.95 (0.88–1.03) | 44.4 | Srivastava et al. (2010) | |
| Asian | Dominant | 2142/4356 | 1.01 (0.90–1.14) | 1.07 (0.87–1.32) | 58.1 | 1596/3957 | 1.03 (0.90–1.17) | 1.08 (0.88–1.32) | 42.4 | Lin et al. (2009), Wang et al. (2007) |
| Recessive | 2142/4356 | 1.05 (0.91–1.21) | 1.11 (0.88–1.40) | 45.8 | – | – | – | – | – | |
| Co-dominant 1 | 2142/4356 | 1.00 (0.88–1.13) | 1.04 (0.86–1.26) | 45.7 | – | – | – | – | – | |
| Co-dominant 2 | 2142/4356 | 1.03 (0.88–1.22) | 1.13 (0.83–1.54) | 59.4 | 1942/4116 | 0.95 (0.80–1.13) | 0.97 (0.77–1.21) | 24.6 | Srivastava et al. (2010) | |
| Additive | 2142/4356 | 1.03 (0.91–1.15) | 1.10 (0.87–1.37) | 66.1 | 1396/3717 | 0.99 (0.87–1.13) | 1.04 (0.83–1.30) | 45.4 | Lin et al. (2009), Srivastava et al. (2010), Wang et al. (2007) | |
| Over-dominant | 2142/4356 | 0.98 (0.88–1.10) | 1.00 (0.87–1.14) | 19.8 | – | – | – | – | – | |
| Allelic | 2142/4356 | 1.02 (0.95–1.11) | 1.08 (0.92–1.26) | 63.6 | 1720/3831 | 1.02 (0.93–1.11) | 1.06 (0.92–1.22) | 41.5 | Lin et al. (2009), Srivastava et al. (2010) | |
| European | Dominant | 3638/5840 | 0.88 (0.81–0.96)⁎ | 0.86 (0.75–0.97)⁎ | 36.8 | – | – | – | – | – |
| Recessive | 3638/5840 | 0.90 (0.80–1.01) | 0.95 (0.79–1.14) | 39.1 | – | – | – | – | – | |
| Co-dominant 1 | 3638/5840 | 0.89 (0.81–0.98)⁎ | 0.85 (0.73–0.98)⁎ | 42.2 | – | – | – | – | – | |
| Co-dominant 2 | 3638/5840 | 0.85 (0.74–0.94)⁎ | 0.87 (0.72–1.05) | 33.3 | – | – | – | – | – | |
| Additive | 3638/5840 | 0.88 (0.80–0.95)⁎ | 0.86 (0.76–0.98)⁎ | 41.5 | – | – | – | – | – | |
| Over-dominant | 3638/5840 | 0.94 (0.86–1.02) | 0.88 (0.76–1.01) | 48.5 | – | – | – | – | – | |
| Allelic | 3638/5840 | 0.91 (0.86–0.97)⁎ | 0.91 (0.84–0.99)⁎ | 31.5 | – | – | – | – | – | |
Dominant model: CT+TT vs. CC for Ala55Val, ID+II vs. DD for 45-bp insertion/deletion, and GA+AA vs. GG for -866G/A.
Recessive model: TT vs. CT+CC for Ala55Val, II vs. ID+DD for 45-bp insertion/deletion, and AA vs. GA+GG for -866G/A.
Co-dominant 1 model: CT vs. CC for Ala55Val, ID vs. DD for 45-bp insertion/deletion, and GA vs. GG for -866G/A.
Co-dominant 2 model: TT vs. CC for Ala55Val, II vs. DD for 45-bp insertion/deletion, and AA vs. GG for -866G/A.
Additive model: 2TT+CT vs. CC for Ala55Val, 2II+ID vs. DD for 45-bp insertion/deletion, and 2AA+GA vs. GG for -866G/A.
Over-dominant model: CT vs. CC+TT for Ala55Val, ID vs. II+DD for 45-bp insertion/deletion, and GA vs. AA+GG for -866G/A.
Allelic model: T vs. C for Ala55Val, I vs. D for 45-bp insertion/deletion, and A vs. G for -866G/A.
DHWE: deviating from Hardy–Weinberg equilibrium.
FEM: fixed effect model; REM: random effect model.
⁎
P < 0.05.