Table 2.
The list of candidate SNPs/genes.
This table lists the 20 candidate SNPs used in search for pair-wise interactions. The Gene name column gives the gene in which the SNP is located; the Disease column gives which disorder the SNP is previously identified to have associations, and the literature source is given in the Reference column. The MAF column contains the minor allele frequency of the SNP calculated by the samples of this study; the OR (T2DM, obesity, hypertension) columns give the odds ratio calculated using current samples by a two-way contingency table, which provides a direct evaluation on the SNP relevant disease risk.
| No | SNP name | Gene name | Disease | MAF | OR |
OR |
OR |
Reference |
|---|---|---|---|---|---|---|---|---|
| T2DM | Obesity | Hypertension | ||||||
| 1 | rs2383208 | CDKN2A/B | T2D | 0.40 | 4.1 | 4.0 | 2.6 | Saxena, Voight et al. (2007) |
| 2 | rs13266634 | CDKAL1 | T2D | 0.45 | 1.2 | 2.1 | 1.8 | Chimienti, Devergnas et al. (2004) |
| 3 | rs4712523 | CDKAL1 | T2D | 0.38 | 2.1 | 0.8 | 2.0 | Steinthorsdottir, Thorleifsson et al. (2007) |
| 4 | rs1111875 | HHEX | T2D | 0.35 | 2.9 | 1.1 | 1.2 | van Vliet-Ostaptchouk, Onland-Moret et al. (2008) |
| 5 | rs4402960 | IGF2BP2 | T2D | 0.21 | 1.0 | 1.4 | 1.9 | Nielson, Czech et al. (1999) |
| 6 | rs5219 | KCNJ11 | T2D | 0.38 | 1.9 | 0.8 | 0.8 | Vaxillaire et al. (2008) |
| 7 | rs1801282 | PPARG | T2D | 0.07 | 1.0 | 5.1 | 0.5 | Altshuler, Hirschhorn et al. (2000) |
| 8 | rs7903146 | TCF7L2 | T2D | 0.04 | 2.7 | 2.4 | 3.1 | Grant, Thorleifsson et al. (2006) |
| 9 | rs10012946 | WFS1 | T2D | 0.08 | 3.0 | 2.8 | 3.6 | Sandhu, Weedon et al. (2007) |
| 10 | rs3751812 | FTO | Obesity | 0.15 | 1.1 | 1.9 | 4.4 | Frayling, Timpson et al. (2007); Hennig, Fulford et al. (2009) |
| 11 | rs662799 | APOA5 | Obesity | 0.32 | 2.0 | 1.9 | 2.6 | Corella, Lai et al. (2007) |
| 12 | rs766605 | INSIG2 | Obesity | 0.03 | 1.8 | 1.7 | 2.4 | Dina, Meyre et al. (2007) |
| 13 | rs10871777 | MC4R | Obesity | 0.12 | 0.6 | 2.4 | 1.1 | Loos, Lindgren et al. (2008) |
| 14 | rs12970134 | MC4R | Obesity | 0.14 | 0.5 | 6.1 | 1.1 | Chambers, Elliott et al. (2008) |
| 15 | rs3772622 | ATGR1 | NAFLD | 0.46 | 0.3 | 1.4 | 0.8 | Yoneda, Hotta et al. (2009) |
| 16 | rs1014290 | SLC2A9 | Hypertension | 0.37 | 3.1 | 3.1 | 3.3 | Vitart, Rudan et al. (2008) |
| 17 | rs6449213 | SLC2A9 | Hypertension | 0.02 | 1.4 | 5.2 | 7.3 | Vitart, Rudan et al. (2008) |
| 18 | rs737267 | SLC2A9 | Hypertension | 0.01 | 0.0 | 5.1 | 7.0 | Vitart, Rudan et al. (2008) |
| 19 | rs3754777 | STK39 | Hypertension | 0.24 | 1.7 | 1.7 | 0.7 | Wang, O'Connell et al. (2009) |
| 20 | rs2383207 | CDKN2BAS | Heart attack | 0.40 | 1.0 | 0.9 | 1.7 | Scheffold et al. (2011) |
MAF is minor allele frequency.
OR is odds ratio.
NAFLD is non-alcoholic fatty liver disease.