Table 3.
Metabolic disorder | SNP sets | Genes | Previous identified associated disorders | Odds ratio of identified sets | Adjusted p-value |
---|---|---|---|---|---|
T2D | (rs2383207, rs5219) | (CDKN2BAS, KCNJ11) | (Heart attack, T2D) | 8.5 | 0.029 |
Obesity | rs4402960 | IGF2BP2 | T2D | 2.4 | 0.045 |
(rs1014290, rs4402960) | (SLC2A9, IGF2BP2) | (Hypertension, T2D) | 6.4 | 0.003 | |
(rs3751812, rs662799) | (FTO, APOA5) | (Obesity, obesity) | 11.7 | 0.007 | |
Hypertension | (rs12970134, rs4402960) | (MC4R, IGF2BP2) | (Obesity, T2D) | 3.0 | 0.002 |
SNP: Single nucleotide polymorphism; T2D: type 2 diabetes.