Table 3.
Significant SNPs found for metabolic disorders.
This table summarizes the SNP sets that are identified in this study to have a significant interaction effect on metabolic disorders. The first column is the associated disorder. The second column gives the SNP sets. The “Genes” column shows in which genes the SNPs are located. The fourth column gives the disorder the genes are previously reported to have associations. The fifth column gives the SNP set's odds ratio. The last column shows the p-values of the SNPs after adjusting by multiple testing.
| Metabolic disorder | SNP sets | Genes | Previous identified associated disorders | Odds ratio of identified sets | Adjusted p-value |
|---|---|---|---|---|---|
| T2D | (rs2383207, rs5219) | (CDKN2BAS, KCNJ11) | (Heart attack, T2D) | 8.5 | 0.029 |
| Obesity | rs4402960 | IGF2BP2 | T2D | 2.4 | 0.045 |
| (rs1014290, rs4402960) | (SLC2A9, IGF2BP2) | (Hypertension, T2D) | 6.4 | 0.003 | |
| (rs3751812, rs662799) | (FTO, APOA5) | (Obesity, obesity) | 11.7 | 0.007 | |
| Hypertension | (rs12970134, rs4402960) | (MC4R, IGF2BP2) | (Obesity, T2D) | 3.0 | 0.002 |
SNP: Single nucleotide polymorphism; T2D: type 2 diabetes.