Figure 3.

Effect of PE on δ-granule quantal release and release kinetics. (A) PE did not influence the amount of serotonin released from single δ-granules. Kinetics of the release (B and C) were also unchanged. (D) Similar numbers of δ-granules were exocytosed from individual platelets with comparable fusion pore stability (E). Cumulative frequencies of the release are similar for each condition (F). (G) Representative amperometric traces from a control platelet (top) and PE-enriched platelet (bottom). Thrombin was applied for 3 s, as indicated by the black bar on traces in part G.