Table 5.
The distribution of heterozygote and homozygote genotypes and mutant allele frequencies of the four thrombophilic gene polymorphisms in all studied groups.
| Case group (n = 193) |
Control group (n = 500) |
Men of the case group (n = 103) |
Women of the case group (n = 90) |
Men of the control group (n = 275) |
Women of the control group (n = 225) |
Men of the case group (n = 103) |
Men of the control group (n = 275) |
Women of the case group (n = 90) |
Women of the control group (n = 225) |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| % | % | P valuea | % | % | P valuea | % | % | P valuea | % | % | P valuea | % | % | P valuea | |
| FV 1691G/Ab | |||||||||||||||
| GA | 11.40 | 4.20 | 0.001 | 13.60 | 8.89 | 0.367 | 4.37 | 4 | 1.000 | 13.60 | 4.37 | 0.005 | 8.89 | 4 | 0.099 |
| AA | 0.00 | 0.00 | NS | 0.00 | 0.00 | NS | 0.00 | 0.00 | NS | 0.00 | 0.00 | NS | 0.00 | 0.00 | NS |
| Frequency of A allele | 5.69 | 2.1 | 0.001 | 6.79 | 4.40 | 0.382 | 2.18 | 2 | 1.000 | 6.79 | 2.18 | 0.006 | 4.40 | 2 | 0.103 |
| FV HR2 4070 A/Gc | |||||||||||||||
| AG | 9.33 | 3.60 | 0.089 | 5.82 | 13.33 | 0.086 | 5.82 | 5.34 | 0.848 | 5.82 | 5.82 | 1.000 | 13.33 | 5.34 | 0.031 |
| GG | 1.56 | 0.00 | 0.021 | 0.98 | 2.23 | 0.599 | 0.00 | 0.00 | NS | 0.98 | 0.00 | 0.272 | 2.23 | 0.00 | 0.081 |
| Frequency of G allele | 6.21 | 2.8 | 0.004 | 3.88 | 8.88 | 0.056 | 2.90 | 2.66 | 0.850 | 3.88 | 2.90 | 0.490 | 8.88 | 2.66 | 0.002 |
| F II 20210 G/Ad | |||||||||||||||
| GA | 10.36 | 6 | 0.051 | 4.86 | 16.66 | 0.009 | 6.19 | 5.78 | 1.000 | 4.86 | 6.19 | 0.806 | 16.66 | 5.78 | 0.004 |
| AA | 1.04 | 0.00 | 0.077 | 0.00 | 2.23 | 0.216 | 0.00 | 0.00 | NS | 0.00 | 0.00 | NS | 2.23 | 0.00 | 0.081 |
| Frequency of A allele | 6.21 | 3 | 0.008 | 2.42 | 10.55 | 0.001 | 3.09 | 2.88 | 1.000 | 2.42 | 3.09 | 0.809 | 10.55 | 2.88 | 0.000 |
| PAI-1 (− 675 I/D, 5G/4G)e | |||||||||||||||
| 5G/4G | 43 | 18.2 | 0.000 | 54.37 | 30 | 0.001 | 17.82 | 18.67 | 0.817 | 54.37 | 17.82 | 0.000 | 30 | 18.67 | 0.035 |
| 4G/4G | 31.1 | 11.2 | 0.000 | 19.42 | 44.45 | 0.000 | 11.64 | 10.67 | 0.777 | 19.42 | 11.64 | 0.064 | 44.45 | 10.67 | 0.000 |
| Frequency of 4G allele | 52.59 | 20.3 | 0.000 | 46.60 | 59.44 | 0.014 | 20.54 | 20 | 0.535 | 46.60 | 20.54 | 0.000 | 59.44 | 20 | 0.000 |
Abbreviations: FV; Factor V, FV HR2; Factor V-His1299 Arg, F II; Factor II or Prothrombin, PAI-1; Plasminogen Activator Inhibitor-1, NS; Nonsignificant.
a
P value calculated by chi-square test.
b
FV, at nucleotide position 1691 on the gene a G was exchanged by an A.
c
FV HR2, at nucleotide position 4070 on the gene an A was exchanged by a G.
d
F II, at nucleotide position 20210 on the gene a G was exchanged by an A.
e
PAI-1, at nucleotide position − 675 on the gene promoter a GGGGG was exchanged by a GGGG.