Table 1.
Morphologic features and hemodynamic analysis of CaMKII DKO and FFFF mice, 5 weeks after I/R surgery
| FFFF |
DKO |
|||
|---|---|---|---|---|
| Sham | I/R | Sham | I/R | |
| Heart weight (mg) | 125.0 ± 16.0 | 127.0 ± 12.5 | 144.0 ± 22.4 | 139.7 ± 13.8 |
| Body weight (g) | 27.2 ± 2.1 | 26.7 ± 2.1 | 27.5 ± 2.9 | 26.0 ± 2.9 |
| HW/BW ratio (mg/g) | 4.6 ± 0.3 | 4.4 ± 1.4 | 5.2 ± 0.4 | 5.2 ± 0.4 |
| Heart rate (bpm) | 358.4 ± 29.5 | 360.0 ± 34.5 | 401.4 ± 30.2 | 390.3 ± 40.1 |
| Ejection fraction (%) | 60.6 ± 4.4 | 44.1 ± 10.9† | 61.3 ± 11.4 | 53.5 ± 10.6‡ |
| dP/dtmax (mmHg/s) | 5,514 ± 1300 | 4,477 ± 1993 | 6,065 ± 989 | 5,702 ± 1661 |
| dV/dtmax (μL/s) | 1,360 ± 546 | 1,295 ± 486 | 1,536 ± 498 | 1,445 ± 531 |
| LVESP (mmHg) | 103.3 ± 13.2 | 83.6 ± 12.0† | 105.0 ± 14.8 | 93.6 ± 9.2‡ |
| LVEDP (mmHg) | 3.6 ± 1.3 | 3.6 ± 1.9 | 2.8 ± 0.9 | 3.3 ± 1.2 |
| SV (μL) | 25.1 ± 4.4 | 20.1 ± 5.8* | 25.8 ± 5.5 | 24.7 ± 9.2 |
| Tau (ms) | 11.6 ± 2.2 | 12.1 ± 2.0 | 9.8 ± 1.1 | 11.6 ± 3.0 |
HW/BW, heart weight/body weight ratio; LVESP, LV end-systolic pressure; LVEDP, LV end-diastolic pressure; SV, stroke volume; Tau, time constant of pressure relaxation.
CaMKII DKO and FFFF mice were subjected to hemodynamic detection 5 weeks after I/R surgery. Data are expressed as mean ± SD of values from nine mice in sham groups and 13 mice in I/R groups.
*
P < 0.05.
†
P < 0.01 versus sham FFFF.
‡
P < 0.05 versus I/R FFFF.