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Kaplan–Meier analysis of the prognostic relevance of CDCA3 and KIF18B downstream predictors in a training dataset of 53 patients with HCC. In all, 143 genes were significantly differentially regulated with dependence on the overexpression of CDCA3, whereas 440 were dependent on KIF18B overexpression. Unsupervised clustering resulted in two different prognostic subgroups. Both (A) CDCA3- and (B) KIF18B-dependent predictors showed a significant difference (P = 0.04, 0.01)
