Table 1.
Summary of the results of dose titration experiments with 20 nucleoside/nucleotide analogues on the expression of the PTC-mutated and the wild-type reporter constructs
| Compound | Upregulation of PTC-mutant reporter luciferase activity | NS39 (EC μM) | Upregulation of wild-type reporter luciferase activity | Wild-type (EC μM) |
|---|---|---|---|---|
| Cytidine | NO | > 50 | NO | > 50 |
| 2′-deoxycytidine | NO | > 50 | NO | > 50 |
| 3′-deoxycytidine | NO | > 50 | NO | > 50 |
| 5-azacytosine | NO | > 50 | NO | > 50 |
| 5-azacytidine | YES | 1.56 | NO | > 50 |
| 5-aza-2′-deoxycytidine | NO | > 50 | NO | > 50 |
| 2′,3′-dideoxycytidine | NO | > 50 | NO | > 50 |
| 2′-deoxycytidine | NO | > 50 | NO | > 50 |
| 2′-O-methylcytidine | NO | > 50 | NO | > 50 |
| 3′-deoxycytidine | NO | > 50 | NO | > 50 |
| 3′-O-methylcytidine | NO | > 50 | NO | > 50 |
| 6-azathymine | NO | > 50 | NO | > 50 |
| 6-azauracil | NO | > 50 | NO | > 50 |
| Cytarabine | NO | > 50 | NO | > 50 |
| Gemcitabine | NO | > 50 | NO | > 50 |
| l-cytidine | NO | > 50 | NO | > 50 |
| N4-aminocytidine | NO | > 50 | NO | > 50 |
| Thymidine | NO | > 50 | NO | > 50 |
| Uridine | NO | > 50 | NO | > 50 |
| Zebularine | NO | > 50 | NO | > 50 |
EC, effective concentration.