Table 2.
Bioactivity Evaluation of Compounds Isolated from A. angustiforlia
| Compound | Bioassay | ||
|---|---|---|---|
| HT-29a | NF-κB (p65)a |
L. mexicana promastigotesb |
|
| 1 | >20 | 1.2 | 183.3 |
| 2 | >20 | >20 | 57.8 |
| 3 | 8.6 | >20 | 104.7 |
| 4 | >20 | >20 | 145.4 |
| 5 | NT | >20 | >200 |
| 6 | >20 | >20 | 138 |
| 7 | 8.0 | >20 | >200 |
| 8 | >20 | >20 | 80.3 |
| 9 | >20 | >20 | 120.4 |
| 10 | 6.5 | >20 | 78 |
| Paclitaxelc | 0.006 | - | - |
| Rocaglamided | 0.005 | 0.08 | - |
| Amphotericin Be | 0.09 | ||
a
Results are expressed as ED50 values (µM); Compounds with ED50 > 20 µM were considered inactive.
b
Results are expressed as IC50 values (µM); Compounds with IC50 >200 µM are considered to be inactive.
c
Used as a positive control substance for HT-29 cell line.
d
Used as a positive control substance for NF-κB (p65) cell line.
e
Used as a positive control substance for L. mexicana promastigote assay.