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. 2015 Jan 8;5:450. doi: 10.3389/fgene.2014.00450

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Copyright © 2015 Vaughn, Foley, Lu, Patel, Zoller, Magnusen, Williams, Ziegler, Comeau, Marion, Glenn, Adler, Shen, Nath, Stevens, Freedman, Tsao, Jacob, Kamen, Brown, Gilkeson, Alarcón, Reveille, Anaya, James, Moser, Criswell, Vilá, Alarcón-Riquelme, Petri, Scofield, Kimberly, Ramsey-Goldman, Binjoo, Choi, Bae, Boackle, Vyse, Guthridge, Namjou, Gaffney, Langefeld, Kaufman, Kelly, Harley, Harley and Kottyan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Step-wise logistic regression analysis reveals one independent genetic effect at the PXK locus. Plot of P values (–log₁₀) following adjustment for genotype at rs4681677. Adjustment for other SNPs with r² > 0.9 with rs4681677 can also account for the genetic association (P < 0.01) in the region.