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. 2014 Nov 27;43(1):309–323. doi: 10.1093/nar/gku1258

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© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Selected human transcripts targeted by SMG6. Transcripts whose PARE MaxSeq decreased by at least 50% and whose mRNA abundance increased significantly (Cuffdiff q < 0.05) in both the siSMG6+siXRN1 and siUPF1+siXRN1 libraries as compared to the siGL2+siXRN1 control are shown. In each case, the magnitude of the effect is represented by a horizontal bar, and the sequence surrounding the principal site of SMG6 cleavage (arrow) is shown. Sequences conforming to the (U/A)-(G/A)-(A/C)-N-(C/U) motif are indicated in red, while sequences with one mismatch are indicated in blue.