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Kinetic analysis of OAS1 activation by RNAs with and without a 3′-ssPy motif. OAS1 activity over a range of VA RNAI and 18-bp dsRNA duplex concentrations both with (solid lines) and without (dashed lines) the 3′-ssPy motif (3′-CUUU and 3′-U, respectively). Data were fit using non-linear regression to obtain the kinetic parameters (Vmax and Kapp) shown in Table 1.
