Figure 7.

Model for 3′-ssPy motif action. Surface representations of the OAS1–dsRNA complex with modeled 3′-ssPy motif (3′-U). The OAS1 loop comprising residues 154 to 165 and the mutated residue that ablates dependence on the 3′-ssPy motif (Gly157) are highlighted. The three views are related by the rotations shown and the ‘left’ image corresponds to the orientation shown in Figure 6. A potential ‘closure’ of the 154–165 loop mediated by 3′-ssPy interaction at the surface comprising G157 is denoted with an arrow (center image).