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Schematic overview of snoRNA timing and DDX21 function in human cells. snoRNPs can be divided into three sets: (1) those that function in early pre-ribosomal complexes (grey), (2) those that are found associated with early and later pre-ribosomal particles (black) and (3) later snoRNAs (red), such as SNORD68 and SNORD56, whose association with pre-40S complexes is regulated by DDX21.
