Table 1. Characteristic sequence specificity in different species. Human and murine behave as antagonist while horse and hamster behave as agonist toward RsLA. Amino acid positions marked with (*) and without asterisks belong to TLR4 and MD2, respectively. Only those residues that have proved influence or expected due to their positions are given. Human proteins were used as references for numbering the residues in both TLR4 and MD2.

Species/Position	Human	Murine	Horse	Hamster
42	Y	F	S	F
57	S	T	T	T
61	L	V	L	L
64	F	E	L	K
65	Y	F	F	F
69	R	G	R	R
73	Q	Y	K	K
82	V	V	M	V
85	M	I	L	I
87	L	L	F	V
89	K	K	M	T
122	K	E	R	K
125	K	L	R	L
369*	E	K	E	E
384*	G	A	R	G
388*	K	S	K	R
397*	G	G	K	G
400*	S	S	R	S
436*	Q	R	Q	K
441*	S	S	P	S
468*	N	L	D	F