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. 2015 Jan 7;5:7657. doi: 10.1038/srep07657

Table 2. Observed ligand binding patterns of TLR4/MD2 complexes and their resulting activities. Prefixes correspond are as follows: h (human), m (murine), e (horse), and ham (hamster).

Effecter activity Complex Orientation Volume of ligand (Å3) Reference
Agonist hTLR4/MD2/LPS Normal 2016 3FXI
Antagonist hTLR4/MD2/RsLA Flipped 1582 Modeled
Antagonist hTLR4/MD2/Eritoran Flipped 1412 2Z65
Antagonist hTLR4/MD2/Lipid IVa Flipped 1393 2E59
Agonist mTLR4/MD2/LPS Normal 2016 3VQ2
Agonist mTLR4/MD2/Lipid IVa Normal 1393 3VQ1
Antagonist mTLR4/MD2/RsLA Normal 1582 Modeled
Agonist eTLR4/MD2/RsLA Normal 1582 Modeled
Agonist hamTLR4/MD2/RsLA Flipped 1582 Modeled