Table 3.
Group differences in resting-state connectivity of the networks of interest with the whole brain.
| Brain regions within the clusters | Hemisphere | Cluster size (mm3) | Peak p-value | MNI coordinates (x, y, z) |
|---|---|---|---|---|
| BEFORE ENCODING | ||||
| The medial visual network (old > young) | ||||
| Frontal pole, superior frontal gyrus | RH | 72 | 0.025 | 15, 48, 33 |
| The default mode network (old < young) | ||||
| Posterior cingulate cortex, precuneus | LH | 820 | 0.006 | −15, −51, 27 |
| Precuneus, posterior cingulate cortex, superior parietal lobule | RH | 221 | 0.024 | 6, −48, 48 |
| LH | 90 | 0.029 | −15, −54, 51 | |
| Lateral occipital cortex, angular gyrus | RH | 141 | 0.028 | 30, −57, 33 |
| Parietal operculum, supramarginal gyrus | LH | 130 | 0.029 | −45, −33, 30 |
| Lingual gyrus, occipital pole | LH | 122 | 0.017 | −3, −90, −18 |
| Angular gyrus, superior parietal lobule, precuneus, lateral occipital cortex | LH | 38 | 0.035 | −18, −60, −39 |
| The left frontoparietal network (old > young) | ||||
| Lateral occipital cortex, precuneus | RH | 1190 | 0.013 | 21, −75, 39 |
| Right crus I and II | RH | 480 | 0.015 | 15, −84, −30 |
| Anterior cingulate cortex, | RH | 270 | 0.019 | 18, 0, 39 |
| supplementary motor area, | LH | 76 | 0.023 | −15, 21, 24 |
| paracingulate cortex | LH | 15 | 0.034 | −9, 36, 0 |
| Occipital fusiform gyrus, lingual gyrus, occipital pole | LH | 227 | 0.019 | −12, −87, −15 |
| Frontal pole | LH | 110 | 0.017 | −36, 42, 0 |
| LH | 78 | 0.027 | −27, 54, −3 | |
| Precuneus, intracalcarine cortex | LH | 100 | 0.034 | −24, −66, 12 |
| Intracalcarine cortex, occipital fusiform gyrus, lingual gyrus | LH | 95 | 0.029 | −24, −75, 6 |
| Posterior cingulate cortex, precentral gyrus, postcentral gyrus, precuneus | LH | 82 | 0.024 | −15, −30, 42 |
| Middle frontal gyrus | RH | 11 | 0.041 | 27, 18, 39 |
| AFTER ENCODING MINUS BEFORE ENCODING | ||||
| The salience network (old after encoding – old before encoding > young after encoding – young before encoding) | ||||
| Posterior parahippocampal gyrus, posterior fusiform gyrus | RH | 15 | 0.019 | 33, −30, −27 |
p-Values refer to the peak of all significant voxels. All p-values < 0.05 are family-wise error (FWE)-corrected at 0.05. Clusters with less than 10 mm3 are not reported. MNI, Montreal Neurological Institute; LH, left hemisphere; RH, right hemisphere. The Harvard-Oxford (sub)cortical and cerebellum atlas provided within FSL were used as anatomical reference.