Table 4.
Resting-state connectivity within the networks of interests within the young and older individuals.
| Brain regions within the clusters | Hemisphere | Cluster size (mm3) | Peak p-value | MNI coordinates (x, y, z) |
|---|---|---|---|---|
| YOUNG: BEFORE ENCODING* | ||||
| The right frontoparietal network | LH/RH | – | <0.001 | – |
| The salience network | LH/RH | – | <0.001 | – |
| The lateral visual network | LH/RH | – | <0.001 | – |
| The medial visual network | LH/RH | – | <0.001 | – |
| The ventral network | LH/RH | – | <0.001 | – |
| The default mode network | LH/RH | – | 0.006 | – |
| The executive network | LH/RH | – | <0.001 | – |
| The left frontoparietal network | LH/RH | – | <0.001 | – |
| OLD: BEFORE ENCODING* | ||||
| The right frontoparietal network | LH/RH | – | <0.001 | – |
| The salience network | LH/RH | – | <0.001 | – |
| The lateral visual network | LH/RH | – | <0.001 | – |
| The medial visual network | LH/RH | – | <0.001 | – |
| The ventral network | LH/RH | – | <0.001 | – |
| The default mode network | LH/RH | – | 0.011 | – |
| The executive network | LH/RH | – | <0.001 | – |
| The left frontoparietal network | LH/RH | – | <0.001 | – |
| YOUNG: AFTER ENCODING MINUS BEFORE ENCODING | ||||
| The default mode network | ||||
| Precuneus | LH | 199 | 0.017 | −18, −63, 18 |
| The executive network | ||||
| Paracingulate cortex, superior frontal cortex | LH | 42 | 0.008 | −6, 15, 51 |
p-Values refer to the peak of all significant voxels. All p-values < 0.05 are family-wise error (FWE)-corrected at 0.05. Clusters with less than 10 mm3 are not reported. MNI, Montreal Neurological Institute; LH, left hemisphere; RH, right hemisphere.
*
For the before encoding time, we have not split up the results in clusters, as the effects involved large areas of the total brain and these effects are not the main interest of the manuscript (see Supplemental Figure 6). The Harvard-Oxford (sub)cortical and cerebellum atlas provided within FSL were used as anatomical reference.