Fig. 5.

Human psoriatic keratinocytes express higher levels of candidate gene transcripts compared with healthy control keratinocytes. Primary keratinocytes were isolated and grown from skin of healthy controls (NN; n = 5) and involved lesional psoriasis skin (PP; n = 5) and gene expression measured and normalized to RPLPO. Significant increases (*p < 0.05) were observed for SerpinB1 and KLK6 and modest increases in Cystatin A (+ p = 0.07) indicative of keratinocytes serving as a key cellular source of each molecule. No increases were observed for Slc25a5 and Rab18.