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HMGB2 and HMGB1 are processed by CCP1. CCP1 is able to cleave the C terminus of A, HMGB1 and B, HMGB2. N-terminally Myc-tagged HMGB1 or HMGB2 were cotransfected with active or inactive CCP1. Equal amounts of each cell extract were analyzed by Western blot using a HA-tag antibody, to show equal expression levels of both CCP1 variants. Western blotting using an anti-Myc antibody shows the appearance of C-terminal processed forms of the HMGB proteins when co-expressed with active CCP1.
