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. 2014 Aug 26;66(9):2590–2600. doi: 10.1002/art.38736

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© 2014 The Authors. Arthritis & Rheumatology is published by Wiley Periodicals, Inc. on behalf of the American College of Rheumatology.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Decreased serum immunoglobulin levels in patients with JIA treated with MTX. A, IgM levels, B, IgG levels, and C, IgA levels in patients with JIA receiving the indicated treatments. Symbols represent individual patients; horizontal lines show the mean ± SEM. ∗ = P < 0.05; ∗∗ = P < 0.01; ∗∗∗ = P < 0.001. See Figure 1 for definitions.