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. 2014 Aug 26;66(9):2590–2600. doi: 10.1002/art.38736

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© 2014 The Authors. Arthritis & Rheumatology is published by Wiley Periodicals, Inc. on behalf of the American College of Rheumatology.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effect of MTX on transitional B cells and immunoglobulin levels in the subgroup of patients with oligoarticular JIA. The effect of MTX was similar to that found when all subgroups of JIA patients were included in the analysis. A, Percentage (left) and absolute number (right) of transitional B cells in untreated patients and patients treated with MTX. B, Percentage (left) and absolute number (right) of mature naive B cells in untreated patients and patients treated with MTX. C, Serum Ig levels in untreated patients and patients treated with MTX. Symbols represent individual patients; horizontal lines show the mean ± SEM. ∗ = P < 0.05; ∗∗ = P < 0.01. See Figure 1 for definitions.