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. 2014 Nov 11;19(1):92–102. doi: 10.1111/jcmm.12463

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© 2014 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

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Fig. 4 — PPARγ-dependent AMPK activity enhanced eNOS expression through regulating LOX-1 receptor. (A and B) The effect of ciglitazone (10 μmol/l) on ox-LDL-induced LOX-1 expression in RMVECs after pre-treated with PPARγ siRNA or GW9662. (C) The effect of ciglitazone (10 μmol/l) on ox-LDL-induced LOX-1 protein levels with or without AMPK siRNA or PPARγ siRNA, respectively. (D) The effect of LOX-1 siRNA on ox-LDL-induced eNOS expression in RMVECs. (E) Relative quantification of nitric oxide production in ox-LDL-induced RMVECs with or without pre-treatment of LOX-1 siRNA.