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miR-24 regulates the intrinsic apoptosis pathways by suppressing the pro-apoptotic protein Bim. Western blot shows little expression of pro-apoptotic proteins Caspase 3, Caspase 12, Caspase 9 and Bim under normal physiological conditions (no MI) and elevated expression after myocardial infarction (MI). miR-24 mice showed reduced levels of pro-apoptotic proteins after MI compared to controls.
