Table 3.
Graft survival in rats grafted with pNb or pNb+MSC
| D28 | D35 | D42 | D63 | D120 | |||||
|---|---|---|---|---|---|---|---|---|---|
| MSC | − | + | − | + | − | + | − | + | + |
| Number of rats | 6 | 5 | 6 | 6 | 6 | 5 | 6 | 6 | 6 |
| NF70orCV+/R7.3− | 4 | 5 | 1 | 6 | 2 | 1 | 0 | 2 | 3 |
| NF70+/R7.3+/− | 1 | 0 | 3 | 0 | 0 | 2 | 0 | 1 | 0 |
| NF70+/R7.3+ | 1 | 0 | 1 | 0 | 2 | 0 | 0 | 1 | 0 |
| NF70−/R7.3+ | 0 | 0 | 1 | 0 | 2 | 1 | 0 | 1 | 0 |
| Scar | 0 | 0 | 0 | 0 | 0 | 1 | 6 | 1 | 3 |
The graft status was assessed using cresyl violet, NF70 and R73 staining. CV+/R73− and NF70+/R73− are considered as healthy graft with no (−) or low (+/−) amount of R73 T cells, no sign of degeneration (CV+) and/or a clear expression of the porcine neurofilament in neurons (NF70+). NF70+R73+ and NF70−R73+ grafts are considered as rejecting and rejected graft respectively. Scar corresponds to the stage of almost complete disappearance of the graft. R73+/− corresponds to a brain with 1–10 T cells per section.