Table 3.
The Children's Oncology Group (COG) risk group classification
| Risk group | Stage (INSS) | Age | Histology | DNA Ploidy | MYCN |
|---|---|---|---|---|---|
| Low risk | Stage 1 | Any | Any | Any | Any |
| Stage 2A/B | <12 months | Any | Any | Any | |
| Stage 2A/B | >12 months | Any | Any | Non-Amplified | |
| Stage 4S | <12 months | Favourable | Hyperdiploid | Non-Amplified | |
| Medium risk | Stage 3 | <12 months | Any | Any | Non-Amplified |
| Stage 3 | >12 months | Favourable | Any | Non-Amplified | |
| Stage 4 | <12 months | Any | Any | Non-Amplified | |
| Stage 4S | <12 months | And/or Unfavourable | And/or Normal | Non-Amplified | |
| High risk | Stage 2A/B | >12 months | Any | Any | Amplified |
| Stage 3 | Any | Any | Any | Amplified | |
| Stage 3 | >18 months | Unfavourable | Any | Any | |
| Stage 4 | Any | Any | Any | Amplified | |
| Stage 4 | >18 months | Any | Any | Any | |
| Stage 4 | >12 months <18 months | And/or Unfavourable | And/or Normal | And/or Amplified | |
| Stage 4S | <12 months | Any | Any | Amplified |