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. Author manuscript; available in PMC: 2015 Jan 9.
Published in final edited form as: Nano Lett. 2013 Oct 21;13(11):5608–5614. doi: 10.1021/nl403252x

Figure 3. Nanoscale spacing of CD16-binding ligands controls NK cell responsiveness.

Figure 3

Plots show NK cell contact area after 6 minutes of cells stimulated on nanoarrays functionalized with anti-CD16 mAb (A) and Rituximab (B). (Left) solid bars show the mean and error bars the standard error in the mean of cell spread area, averaged for each donor and then across donors. Data are normalized to PLL for each donor to enable comparison, with significance determined using a non-parametric Mann-Whitney test: *** p < 0.001. (Right) Donor by donor comparison of the cell-nanoarray contact area at 25 nm and 104 nm: lines indicate data points from the same donor.