Fig. 1.

Study design. The hypotheses of this study were that heterogeneous susceptibility to tumor-associated seizure exists between brain regions and that tumors involving specific brain regions could be associated with increased seizure risk. To test these hypotheses, we first prospectively examined a discovery set cohort by performing a regression-model based analysis to locate the tumor-associated seizure-susceptible regions. These VLSM-identified regions were subsequently validated by an external dataset to examine whether the identified regions were associated with increased seizure incidence in tumor patients. DICOM, Digital Imaging and Communications in Medicine (file format).